Double-blind evaluation of mazindol in refractory obesity.

These results in a few patients suggest that doxantrazole may be valuable in the treatment of asthma. A similar protection against asthma induced by allergen challenge has been reported for the orally administered compound AH 7725,3 but the value of disodium cromoglycate was proved by long-term trials4 rather than such singledose studies. Further clinical trials are obviously needed to establish the long term efficacy of doxantrazole and determine which patients are likely to respond. Nevertheless, these preliminary findings are encouraging. Apart from difficulties with the Spinhaler an important disadvantage of cromoglycate is that it may cease to be effective in patients with severe airways obstruction because it is not effectively inhaled into their lungs.5 An orally active drug should be effective however severe the degree of airways obstruction.